Side-effects of epidural narcotics.

Nausea and vomiting Depends on plasma concentration of narcotic. Incidence 10-25% with Fentanyl/Morphine/Pethidine Pruritus Up to 50% with Morphine (only 5% severe). 15-35% with Fentanyl/ Pethidine. Respiratory depression Delayed onset with Morphine (up to 12 hours). May occur within 2-3 hours for Fentanyl/Pethidine. Less sedation with toleance to narcotics Urinary retention Synergistic effect with local anaesthetics (10-40%)