Comparative CNS and CVS Toxicity

Drug Cumulative convulsive dose (Mean +/- SEM) Cumulative lehal dose (Mean +/- SEM) CV/CNS
Lidocaine 22.0 +/- 6.7 76.2 +/- 15.1 3.5
Etidocaine 8.0 +/- 2.2 40.4 +/- 6.0 5.1
Tetracaine 4.0 +/- 2.2 26.9 +/- 4.6 6.7
Bupivacaine 5.0 +/- 0 20.4 +/- 2.4 4.1

Liu PL:
Anesth Analg 62:375, 1983